{"id":4487,"date":"2020-01-17T12:28:27","date_gmt":"2020-01-17T12:28:27","guid":{"rendered":"https:\/\/byndbotanicals.wpengine.com\/?page_id=4487"},"modified":"2023-04-06T11:09:11","modified_gmt":"2023-04-06T15:09:11","slug":"cbd-and-the-endocannabinoid-system","status":"publish","type":"page","link":"https:\/\/beyondbotanicals.com\/cbd-and-the-endocannabinoid-system\/","title":{"rendered":"CBD and the Endocannabinoid System"},"content":{"rendered":"\n  <div class=\"banner has-hover has-parallax\" id=\"banner-270533284\">\n          <div class=\"banner-inner fill\">\n        <div class=\"banner-bg fill\" data-parallax=\"-8\" data-parallax-container=\".banner\" data-parallax-background>\n            <div class=\"bg fill bg-fill \"><\/div>\n                                    \n                    <\/div>\n\t\t\n        <div class=\"banner-layers container\">\n            <div class=\"fill banner-link\"><\/div>            \n   <div id=\"text-box-672887196\" class=\"text-box banner-layer x50 md-x50 lg-x0 y30 md-y40 lg-y40 res-text\">\n                                <div class=\"text-box-content text dark\">\n              \n              <div class=\"text-inner text-center\">\n                  \n<h1 style=\"text-align: left;\"><span style=\"font-size: 100%;\">CBD AND THE ENDCANNABINOID SYSTEM<\/span><\/h1>\n              <\/div>\n           <\/div>\n                            \n<style>\n#text-box-672887196 {\n  width: 76%;\n}\n#text-box-672887196 .text-box-content {\n  font-size: 100%;\n}\n@media (min-width:550px) {\n  #text-box-672887196 {\n    width: 85%;\n  }\n}\n<\/style>\n    <\/div>\n \n        <\/div>\n      <\/div>\n\n            \n<style>\n#banner-270533284 {\n  padding-top: 463px;\n  background-color: rgb(255, 255, 255);\n}\n#banner-270533284 .bg.bg-loaded {\n  background-image: url(https:\/\/beyondbotanicals.com\/wp-content\/uploads\/2020\/01\/cbd-and-the-endocannabinoid-system-explained-beyond-botanicals-cbd.jpg);\n}\n#banner-270533284 .bg {\n  background-position: 64% 0%;\n}\n#banner-270533284 .ux-shape-divider--top svg {\n  height: 150px;\n  --divider-top-width: 100%;\n}\n#banner-270533284 .ux-shape-divider--bottom svg {\n  height: 150px;\n  --divider-width: 100%;\n}\n@media (min-width:550px) {\n  #banner-270533284 {\n    padding-top: 531px;\n  }\n}\n<\/style>\n  <\/div>\n\n\n\t<section class=\"section faq-section dark\" id=\"section_477567881\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<div class=\"row align-center\"  id=\"row-1469032487\">\n\n\t<div id=\"col-1313377859\" class=\"col videoButton medium-10 small-12 large-10\"  >\n\t\t\t\t<div class=\"col-inner text-center\"  >\n\t\t\t\n\t\t\t\n<h2 style=\"text-align: center;\"><span style=\"font-size: 170%; color: #699d3b;\"><span class=\"lgt-intro\">Learn About Cannabis Chemistry<\/span><\/span><\/h2>\n<p><span style=\"color: #808080;\">To understand CBD and the endocannabinoid system, you need to start with a history lesson. Even before researchers discovered the endocannabinoid system, cannabis has had a role in folk medicine for millennia. Historically, practitioners have used it to address a myriad of health issues. Investigation into the benefits of cannabis led to the discovery of chemical compounds within the plant called cannabinoids. <\/span><span style=\"color: #808080;\">There are over 80 different types of cannabinoids present in cannabis, depending on the cultivar. The two most frequently referenced are Cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC). CBD is a non-intoxicating cannabinoid. THC is intoxicating.<\/span><span style=\"color: #808080;\">Scientists isolated cannabidiol for the first time in the 1940s. However, it wasn\u2019t until the mid-1960s that research into the psychotropic effects of the plant led to the isolation of THC by Dr. Raphael Mechoulam and colleagues. The discovery of CBD and THC sparked an interest in the scientific community for further research. Their discoveries illuminated the unique properties of these compounds and how they are utilized by the human body. Ultimately, this led to the discovery of what has become known as the Endocannabinoid System (ECS).<\/span><\/p>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n<div class=\"row align-center\"  id=\"row-1514695782\">\n\n\t<div id=\"col-1236892069\" class=\"col videoButton medium-10 small-12 large-10\"  >\n\t\t\t\t<div class=\"col-inner text-center\"  >\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<h3 style=\"text-align: center;\"><span style=\"font-size: 170%; color: #699d3b;\"><span class=\"lgt-intro\">The Endocannabinoid System<\/span><\/span><\/h3>\n<p><span style=\"color: #808080;\">The Endocannabinoid System, or ECS, is a set of cell receptors in the human body and a specific set of molecules that are capable of attaching to those receptors. These molecules and receptors function in a way that is similar to a circuit and battery. There are two primary receptors on this pathway, CB1 and CB2. CB1 receptors reside primarily within the central nervous system, as well as throughout the body in lower concentrations. You can find CB2 receptors on immune cells and in blood cell precursors, as well as other bodily tissues.\u00a0<\/span><span style=\"color: #808080;\">Chemical compounds that bind to these receptors and activate the pathways are called agonists, while those that bind and prevent the pathway from being activated are called antagonists. THC is considered an agonist, as it can bind directly to the CB1 and CB2 receptors to \u201cturn on\u201d those pathways. Activation of these pathways have been shown to influence several systems associated with well-being, physical sensation, and more.\u00a0<\/span><\/p>\n<\/div>\n\t<div id=\"gap-1847504209\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1847504209 {\n  padding-top: 0px;\n}\n@media (min-width:550px) {\n  #gap-1847504209 {\n    padding-top: 30px;\n  }\n}\n<\/style>\n\t<\/div>\n\t\n\t<div id=\"gap-1849747850\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1849747850 {\n  padding-top: 0px;\n}\n@media (min-width:550px) {\n  #gap-1849747850 {\n    padding-top: 60px;\n  }\n}\n<\/style>\n\t<\/div>\n\t\n\n  <div class=\"banner has-hover hide-for-small\" id=\"banner-28339195\">\n          <div class=\"banner-inner fill\">\n        <div class=\"banner-bg fill\" >\n            <div class=\"bg fill bg-fill \"><\/div>\n                                    \n                    <\/div>\n\t\t\n        <div class=\"banner-layers container\">\n            <div class=\"fill banner-link\"><\/div>            \n        <\/div>\n      <\/div>\n\n              <div class=\"height-fix is-invisible\"><img width=\"1600\" height=\"947\" src=\"https:\/\/beyondbotanicals.com\/wp-content\/uploads\/2020\/02\/BBSite_doc_1.jpg\" class=\"attachment-original size-original\" alt=\"BBSite doc 1\" decoding=\"async\" loading=\"lazy\" srcset=\"https:\/\/beyondbotanicals.com\/wp-content\/uploads\/2020\/02\/BBSite_doc_1.jpg 1600w, https:\/\/beyondbotanicals.com\/wp-content\/uploads\/2020\/02\/BBSite_doc_1-510x302.jpg 510w, https:\/\/beyondbotanicals.com\/wp-content\/uploads\/2020\/02\/BBSite_doc_1-300x178.jpg 300w, https:\/\/beyondbotanicals.com\/wp-content\/uploads\/2020\/02\/BBSite_doc_1-1024x606.jpg 1024w, https:\/\/beyondbotanicals.com\/wp-content\/uploads\/2020\/02\/BBSite_doc_1-768x455.jpg 768w, https:\/\/beyondbotanicals.com\/wp-content\/uploads\/2020\/02\/BBSite_doc_1-1536x909.jpg 1536w\" sizes=\"(max-width: 1600px) 100vw, 1600px\" \/><\/div>\n            \n<style>\n#banner-28339195 {\n  padding-top: 553px;\n  background-color: rgb(255, 255, 255);\n}\n#banner-28339195 .bg.bg-loaded {\n  background-image: url(https:\/\/beyondbotanicals.com\/wp-content\/uploads\/2020\/02\/BBSite_doc_1.jpg);\n}\n#banner-28339195 .ux-shape-divider--top svg {\n  height: 150px;\n  --divider-top-width: 100%;\n}\n#banner-28339195 .ux-shape-divider--bottom svg {\n  height: 150px;\n  --divider-width: 100%;\n}\n<\/style>\n  <\/div>\n\n\n\t<div id=\"gap-1393585330\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1393585330 {\n  padding-top: 0px;\n}\n@media (min-width:550px) {\n  #gap-1393585330 {\n    padding-top: 60px;\n  }\n}\n<\/style>\n\t<\/div>\n\t\n<div class=\"text-center\"><div class=\"is-divider divider clearfix\" style=\"max-width:100px;height:1px;background-color:rgb(125, 176, 79);\"><\/div><\/div>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_477567881 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n  background-color: rgb(255,255,255);\n}\n#section_477567881 .ux-shape-divider--top svg {\n  height: 150px;\n  --divider-top-width: 100%;\n}\n#section_477567881 .ux-shape-divider--bottom svg {\n  height: 150px;\n  --divider-width: 100%;\n}\n<\/style>\n\t<\/section>\n\t\n\t<section class=\"section\" id=\"section_1656509765\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<div class=\"row align-center\"  id=\"row-838379960\">\n\n\t<div id=\"col-1287043540\" class=\"col videoButton medium-10 small-12 large-10\"  >\n\t\t\t\t<div class=\"col-inner text-center\"  >\n\t\t\t\n\t\t\t\n<h4 style=\"text-align: center;\"><span style=\"font-size: 170%; color: #699d3b;\"><span class=\"lgt-intro\">Follow Your Bliss (Molecule)<\/span><\/span><\/h4>\n<p><span style=\"color: #808080;\">Cannabinoids are not made naturally by the body, so the presence of receptors that were specifically triggered by these compounds made scientists question whether the body produced its own chemicals similar to cannabinoids. Further digging revealed a set of endogenous (internal) molecules that are manufactured by the body and activate this pathway, dubbed endocannabinoids. There are two primary endocannabinoids: anandamide, also known as the bliss molecule (from the sanskrit word <i>ananda <\/i>meaning bliss), and 2-Ag (2-arachidonoyl glycerol).<\/span><span style=\"color: #808080;\">Anandamide and 2-Ag both function in a way similar to THC; they bind to CB1 and CB2 receptors, and activate the pathways those receptors connect to. In addition to acting as agonists for the ECS, anandamide and 2-Ag are also antagonists for a separate receptor, known as the vanilloid receptor, which is responsible for regulation physical sensation. Studies show that 2-Ag has demonstrates neuroprotective effects. <\/span><span style=\"color: #808080;\">In addition, researchers discovered two enzymes responsible for metabolizing (processing\/altering) endocannabinoid compounds, Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). CB1 and CB2 receptors, endocannabinoids, and enzymes interact in different ways to produce a series of chain reactions along the ECS. The target receptors, the tissues they are in, and the type of molecules triggering the receptors determine the specific effects.<\/span><\/p>\n<div id=\"gtx-trans\" style=\"position: absolute; left: 390px; top: 142.359px;\">\n<div class=\"gtx-trans-icon\"><\/div>\n<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n<div class=\"row row-large align-middle align-center\"  id=\"row-632731294\">\n\n\t<div id=\"col-128620356\" class=\"col medium-10 small-12 large-10\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h5 style=\"text-align: center;\"><span style=\"font-size: 170%; color: #699d3b;\"><span class=\"lgt-intro\">CBD &amp; The Endocannabinoid System<\/span><\/span><\/h5>\n<p style=\"text-align: center;\"><span style=\"color: #808080;\">Unlike THC, CBD (Cannabidiol) doesn\u2019t really bind to either of the CB receptors. However, many studies have shown that CBD has a significant effect on the functioning of the ECS. Many scientists believe that CBD exerts its influence by interacting with FAAH to prevent the enzyme from breaking down anandamide present in the body. By inhibiting FAAH, the amount of circulating anandamide increases. This means that the effects anandamide has along the ECS pathways increase, too.<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"color: #808080;\">Additionally, CBD is a powerful antioxidant, is capable of increasing the production of 2-Ag (an ECS agonist), and interacts with other receptors in the body beyond the ECS to produce a wide range of beneficial effects. Studies also suggest that CBD has the potential to modulate the psychoactive properties of THC in certain ratios. Current research on CBD and the Endocannabinoid System is especially important. Scientists are exploring CBD&#8217;s potential capability. Although the FDA prohibits us from making medical claims, you can view <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/\">published studies on the effects of CBD through the PubMed database<\/a>.\u00a0<\/span><\/p>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n<div class=\"row align-center\"  id=\"row-181097936\">\n\n\t<div id=\"col-1809588677\" class=\"col videoButton medium-10 small-12 large-10\"  >\n\t\t\t\t<div class=\"col-inner text-center\"  >\n\t\t\t\n\t\t\t\n<h5 style=\"text-align: center;\"><span style=\"font-size: 170%; color: #699d3b;\"><span class=\"lgt-intro\">Beneficial Uses of CBD<\/span><\/span><\/h5>\n<p><span style=\"color: #808080;\">As more researchers delve into understanding how CBD and the Endocannabinoid System work together, the clearer it becomes that the ECS plays a role in almost every bodily system, including supporting healthy metabolisms and nervous systems.<\/span><\/p>\n<p><span style=\"color: #808080;\">This is a brief overview of the functioning of a very complex system intended to provide basic understanding. There are many resources that can provide an in-depth explanation of the more complicated functioning of the endocannabinoid system. To help you start, we listed some of the resources used for this article below.<\/span><\/p>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n<div class=\"row row-large align-middle align-center\"  id=\"row-1522654658\">\n\n\t<div id=\"col-260992081\" class=\"col medium-5 small-12 large-5\"  >\n\t\t\t\t<div class=\"col-inner text-center\"  >\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1708487606\" class=\"col medium-5 small-12 large-5\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h2 style=\"text-align: center;\"><span class=\"p-sub-title\">Resources<\/span><\/h2>\n<p><span style=\"color: #808080;\">The Endocannabinoid System as an Emerging Target of Pharmacotherapy. <i>Pharmacological Reviews<\/i>, <i>58<\/i>(3), 389\u2013462. <a style=\"color: #808080;\" href=\"http:\/\/doi.org\/10.1124\/pr.58.3.2\">http:\/\/doi.org\/10.1124\/pr.58.3.2 <\/a><\/span><span style=\"color: #808080;\">Pizzorno, L. (2006). New Developments in Cannabinoid-Based Medicine: an interview with Dr. Raphael Mechoulam. Retrieved from: <a style=\"color: #808080;\" href=\"http:\/\/cannabisclinicians.org\/interview-with-dr-raphael-mechoulam\/\">http:\/\/cannabisclinicians.org\/interview-with-dr-raphael-mechoulam\/<\/a><\/span><\/p>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_1656509765 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n#section_1656509765 .ux-shape-divider--top svg {\n  height: 150px;\n  --divider-top-width: 100%;\n}\n#section_1656509765 .ux-shape-divider--bottom svg {\n  height: 150px;\n  --divider-width: 100%;\n}\n<\/style>\n\t<\/section>\n\t\n\t<section class=\"section\" id=\"section_1248374496\">\n\t\t<div class=\"bg section-bg fill bg-fill  bg-loaded\" >\n\n\t\t\t\n\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n\t\t<\/div>\n\n\t\t\n<style>\n#section_1248374496 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n}\n#section_1248374496 .ux-shape-divider--top svg {\n  height: 150px;\n  --divider-top-width: 100%;\n}\n#section_1248374496 .ux-shape-divider--bottom svg {\n  height: 150px;\n  --divider-width: 100%;\n}\n<\/style>\n\t<\/section>\n\t\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":7,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>CBD &amp; The Endocannabinoid System | Beyond Botanicals | CBD Oil<\/title>\n<meta name=\"description\" content=\"Learn how CBD (cannabidiol) acts on the body&#039;s endocannabinoid system to achieve myriad beneficial effects without having any psychoactive properties.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondbotanicals.com\/cbd-and-the-endocannabinoid-system\/\" 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